Spider-Man 4

After watching Spider-Man 3, I’m pretty sure there would be a 4th installment. And this was confirmed by director Sam Raimi saying that Sony Pictures would not only be doing the 4th but also the 5th and 6th installments of the popular franchise. 

Some things were left unsettled in Spider-Man 3, like that alien symbiote piece left at Dr. Curt Connors lab, with the possibility of escaping from its container and transforming him to the Lizard, one of Spidey’s enemies in the Marvel comics universe. Another thing is the Sandman disappearing to nowhere. He’s still alive and that makes me suspicious about his next move. Note that these villains are not your ordinary crooks with tattoos, they're extremely dangerous!
 

Spidey fans at the official site’s message boards are discussing about new villains surfacing like Carnage and the possibility of the Goblins coming back. Well, I would like Venom to be resurrected in 4 though. I’m sure he would give Spidey some challenge, though too many villainous characters might ruin the plot. 

Photos from Spider-Man 3 official site